多潘立酮与消化酶联合治疗功能性消化不良疗效分析

Efficacy analysis of domperidone tablets combined with digestive enzymes in the treatment of functional dyspepsia

目的:探讨多潘立酮联合消化酶治疗功能性消化不良的临床效果。方法:选取功能性消化不良患者130例,随机分为两组,对照组59例,观察组71例,两组患者一般资料比较,差异无统计学意义(P>0.05),具有可比性;对照组患者给予单纯多潘立酮口服治疗,观察组患者在对照组基础上给予消化酶联合治疗,比较两组患者治疗效果,以及治疗前后症状积分。结果:观察组患者治愈率和有效率分别为50.70%和95.77%,均明显高于对照组患者28.81%和77.97%的比例;经过治疗两组患者上腹痛、恶心呕吐、上腹部灼痛、反酸、嗳气等症状均有所好转,其中观察组患者好转更为明显,两组比较差异有统计学意义(P<0.05)。结论:多潘立酮与消化酶联合应用治疗功能性消化不良是一种简便而有效的方式,在临床工作中可以作为常规的治疗方式进行推广。

Objective To investigate the clinical effects for domperidone tablets combined with digestive enzymes in the treatment of functional dyspepsia.Method 130 cases with functional dyspepsia were chosen as the research object.They were divided into two groups,the control group was 59 cases,and the observation group was 71 cases.It was comparable for these two groups.The patients in the control group were given pure domperidone oral treatment,and patients in the observation group were given digestive enzyme combination therapy on the basis of the control group.The treatment effect of the two groups as well as the symptom score before and after treatment was compared.Results The cure rate and efficiency rate were 50.70% and 95.77%,and they were significantly higher than those in the control group of 28.81% and 77.97%.After treatment,the abdominal pain,nausea,vomiting,heartburn,acid reflux,belching and other symptoms had improved in these two groups of patients.The observation group improved more significantly.The above comparison was significantly different,and with statistically significance（P0.05）.Conclusion Domperidone combined with digestive enzymes in the treatment of functional dyspepsia is a simple and effective way,and it should be promoted as a routine treatment in the clinical work.