肥厚型心肌病患者血管紧张素转换酶基因缺失多态性研究

Angiotensin-converting Enzyme Gene Polymorphisms in Hypertrophic Cardiomyopathy

目的 探讨血管紧张素转换酶 ( ACE)基因插入 /缺失 ( I/ D)多态性与肥厚型心肌病 ( HCM)发病的关系。方法 应用 PCR技术扩增 ACE基因目的片段检测基因多态性。结果 HCM患者与正常对照组的 D等位基因频率及 DD基因型分布有显著性差异 ( P<0 .0 1,P<0 .0 5 ) ,DD基因型 HCM患者心脏事件发生率及左室壁厚度明显大于 、ID基因型 HCM患者( P<0 .0 1,P<0 .0 1) ,家族性肥厚型心肌病 ( FHCM)和散发性肥厚型心肌病 ( SHCM)患者的 ACE基因的等位基因频率及基因型分布无显著性差异 ( P>0 .0 5 )。结论 ACE I/ D基因多态性与 HCM发病有关 ,DD基因型是

Objective To investigate the relation between the contribution of the angiotensinconverting enzyme (ACE) gene polymorphisms and hypertrophic cardiomyopathy (HCM). Methods The polymorphism of ACE gene was analyzed with polymerase chain reaction (PCR). Results Dallele frequencies and DD genotype frequencies were higher in HCM patients than those in control subjects (P<0.01,P<0.05). The cardiac events and the degree of left ventricular hypertrophy were also much higher in DD genotype of HCM patients than those in other genotypes of HCM patients (P<0.01,P<0.01). There were no significant differences in Dallele frequencies and DD genotype frequencies between patients of familial HCM(FHCM) and solitary HCM(SHCM)(P>0.05). Conclusion The ACE gene polymorphism are associated with HCM, and DD genotype of ACE gene is a risk factor for cardiac events and left ventricular hypertrophy in HCM patients.