组织多肽特异性抗原对小细胞肺癌诊断价值的Meta分析

Diagnostic accuracy of tissue polypeptide specific antigen for small cell lung cancer:A meta analysis

目的通过Meta分析评估血清组织多肽特异性抗原(tissue polypeptide specific antigen,TPS)对小细胞肺癌(small cell lung cancer,SCLC)的诊断价值。方法收集已公开发表的有关TPS诊断SCLC的文献,通过纳入及排除标准获取文献并提取数据,采用Meta Disc 1.4软件对数据进行Meta分析。结果 Meta结果示血清TPS诊断小细胞肺癌的敏感度(sensitivity)0.66(95%CI为0.62～0.69)、特异度(specificity)0.84(95%CI为0.82～0.86)、诊断比值比(diagnostic odds ratio,DOR)7.55(95%CI为6.00～9.50)、综合受试者工作特征(the summary receive operating characteristic,SROC)曲线下面积(AUC)0.80,Q指数为0.73。结论血清TPS对小细胞肺癌有一定诊断价值,可提高小细胞肺癌诊断准确度,但需要更多高质量、大样本、多中心的研究加以验证。

Objective To assess the diagnostic value of serum tissue polypeptide specific antigen（TPS） for small cell lung cancer（SCLC） by Meta-- analysis. Methods Researches about the clinical usage of TPS for the diagnosis of SCLC were retrieved according to the inclusion and exclusion criteria, and data extracted from enrolled literatures were analyzed by Meta Disc 1.4 software. Results The summary estimates for TPS in the diagnosis of SCLC were： sensitivity 0.66 [95% confidence interval （CI）, O. 62-0.69-], specificity 0.84 （95% CI, O. 82-0.86）, diagnostic odds ratio 7.55 （95% CI, 6.00-9.50） ,The area under SROC curve（AUC）and Q index were 0. 80, 0.73 respectively. Conclusion The determination of serum TPS may improve the accuracy of SCLC diagnosis, but need more high quality, large sample and multicenter studies.