基质金属蛋白酶-9对恶性胸腔积液诊断价值的Meta分析

Diagnostic Value of Matrix Metalloproteinase 9 for Malignant Pleural Effusion:A Meta Analysis

目的通过Meta分析探讨基质金属蛋白酶-9(MMP-9)对恶性胸腔积液(MPE)的诊断价值。方法计算机及手工检索获得2012年10月之前发表的MMP-9诊断恶性胸腔积液的文献。根据纳入及排除标准筛选文献并提取数据。应用Meta-DiSc软件检验研究间异质性,并对诊断效能指标进行Meta分析,绘制综合受试者工作特征曲线(SROC)。结果 MMP-9诊断MPE的总灵敏度、总特异度分别为0.754(95%CI:0.709～0.795)、0.714(95%CI:0.663～0.761),合并DOR为9.161(95%CI:6.520～12.872)。SROC曲线下面积AUC为0.8179,Q指数为0.7517。结论 MMP-9对于MPE的筛查具有一定价值,但不足以单一应用诊断MPE。

Objective To study the diagnostic value of matrix metalloproteinase-9（MMP-9） for malignant pleural effusion（MPE） by Meta-analysis. Methods We searched the literatures published before October 2012 about the MMP-9 in the diagnosis of MPE and extracted data according to inclusion and exclusion criteria. Meta-DiSc software was applied to test the heterogeneity between studies, Meta-analysis was used to analyze Diagnosis efficiency indexes and the summary receive operating characteristic （SROC） curve was plotted. Results Comprehensive sensitivity, specificity and diagnostic odds ratio were 0. 754（95% CliO. 709-0. 795）,0. 714（95% CI：O. 663-0. 761）and 9. 161（95 % CI..6. 520-12. 872）, respectively. AUC was 0. 8179,and Q index was 0. 7517. Conclusion MMP-9 plays a role in screening MPE, but it is not enough to be used as a single method to diagnose MPE.