摘要
目的通过Meta分析探讨基质金属蛋白酶-9(MMP-9)对恶性胸腔积液(MPE)的诊断价值。方法计算机及手工检索获得2012年10月之前发表的MMP-9诊断恶性胸腔积液的文献。根据纳入及排除标准筛选文献并提取数据。应用Meta-DiSc软件检验研究间异质性,并对诊断效能指标进行Meta分析,绘制综合受试者工作特征曲线(SROC)。结果 MMP-9诊断MPE的总灵敏度、总特异度分别为0.754(95%CI:0.709~0.795)、0.714(95%CI:0.663~0.761),合并DOR为9.161(95%CI:6.520~12.872)。SROC曲线下面积AUC为0.8179,Q指数为0.7517。结论 MMP-9对于MPE的筛查具有一定价值,但不足以单一应用诊断MPE。
Objective To study the diagnostic value of matrix metalloproteinase-9(MMP-9) for malignant pleural effusion(MPE) by Meta-analysis. Methods We searched the literatures published before October 2012 about the MMP-9 in the diagnosis of MPE and extracted data according to inclusion and exclusion criteria. Meta-DiSc software was applied to test the heterogeneity between studies, Meta-analysis was used to analyze Diagnosis efficiency indexes and the summary receive operating characteristic (SROC) curve was plotted. Results Comprehensive sensitivity, specificity and diagnostic odds ratio were 0. 754(95% CliO. 709-0. 795),0. 714(95% CI:O. 663-0. 761)and 9. 161(95 % CI..6. 520-12. 872), respectively. AUC was 0. 8179,and Q index was 0. 7517. Conclusion MMP-9 plays a role in screening MPE, but it is not enough to be used as a single method to diagnose MPE.
出处
《西部医学》
2013年第1期12-15,共4页
Medical Journal of West China
基金
国家科技支撑计划"常见和多发呼吸疾病防治研究"(2012BAI05B02)