DNA异倍体检测对恶性胸腔积液诊断价值的Meta分析

Estimate DNA aneuploid detection in in the diagnosis of malignant pleural effusion by Meta-analysis

目的系统评价DNA异倍体检测对恶性胸腔积液的诊断价值并作Meta分析。方法计算机检索CNKI、万方、维普、Medline、Embase、Cochrane Library等数据库,筛选关于DNA异倍体检测对恶性胸腔积液诊断价值的中英文文献并进行系统评价。对纳入的文献,采用QUADAS进行质量评价,MetaDis 1.4及Stata软件进行Meta分析。结果共纳入符合要求的文献19篇,合并敏感度为0.74(95%CI:0.70～0.77),合并特异度为0.94(95%CI:0.92～0.95),合并阳性似然比为9.60(95%CI:7.53～12.24),合并阴性似然比为0.29(95%CI:0.25～0.32),合并诊断优势比为32.95(95%CI:24.01～45.22),SROC曲线下面积为0.8788。结论 DNA异倍体检测对恶性胸腔积液诊断有一定价值,其诊断准确程度中等。

Objective To evaluate the accuracy of DNA aneuploid detection in the diagnosis of malignant pleural effusion by Meta--analysis. Methods Researches about DNA aneuploid detection in the diagnosis of malignant pleural effusion were retrieved in CNKI, WANFANG DATA, WEIPU DATA, Medline, Embase and Cochrane Library. QUA- DAS was used to evaluate the quality evaluation of these articles. Statistical analysis was performed by employing Meta- Disc 1.4 software and Stata. Results Nineteen studies were adopted in the analysis. The summary estimates for DNA aneuploidy detection in the diagnosis of malignant pleural effusion were： sensitivityO. 74 （95%CI, O. 70-0. 77）, specificity0.94（95%CI, 0. 92-0. 95） , positive likelihood ratio 9.60（95%CI, 7.53-12.24）, negative likelihood ratio 0.29（95% CI, O. 25-0.32）, diagnostic odds ratio 32.95 （95% CI, 24.01-45.22）, and the AUC of SROC was 0. 8788. Conclusion DNA aneuploidy detecion plays a valuable role in the diagnosis of malignant pleural effusion, and the diagnostic accuracy is moderate.