银屑病的流行病学与危险因素

The prevalence and risk factors of psoriasis

银屑病是一种常见的慢性、复发性、炎症性皮肤病。银屑病在世界各地不同人群中的患病率有明显差异,欧美报告的患病率约1%～3%,1984年我国银屑病的患病率为0.123%,2008年流行病学调查显示患病率为0.47%,男女分布相近,提示我国银屑病的患病率有升高趋势。银屑病的发病与遗传和环境因素相关。致病基因尚未找到,发现了一系列易感基因。环境因素中,寒冷、吸烟、嗜酒、感染、外伤、潮湿可能是银屑病发病危险因素,近年来的研究显示,银屑病易患糖尿病、高脂血症和心血管疾病。

Psoriasis is a recurrent and chronic inflammatory skin disease. The prevalence of psoriasis varied among different ethnic groups worldwide. The prevalence of psoriasis in Europe and North America is approximately 1% -3%. In China, the prevalence of psoriasis reported in 1984 was 0. 123% ,while it became 0. 47% with no gender differences in a study performed in 2008 ,suggesting that the prevalence of psoriasis in China had increased during past 30 years. The pathogenesis of psoriasis is associated with genetic and environmental factors. However, the disease-related gene of psoriasis has not been found yet, while a series of predisposing genes for psoriasis has been discovered. The risk factors of psoriasis include cold weather, smoking, alcohol abuse, infections, trauma and so on. Recent studies suggest that psoriasis is strongly associated with diabetes, hyperlipidemia and cardiovascular diseases.