C13orf31基因单核苷酸多态性与彝族麻风病相关性的研究

The corelation between the single nucleotide polymorphisms of C13orf31 gene and leprosy in yi chinese population

目的研究C13orf31基因单核苷酸多态性(SNP)位点与中国彝族人群麻风病的关系。方法采用单碱基延伸法(SNaP shot)检测300例彝族麻风病患者(麻风病组)和300例彝族健康者(对照组)C13orf31基因的2个SNP:rs3764147、rs10507522的基因型。结果 rs3764147和rs10507522这2个位点的基因型分布均符合Hardy-Weinberg平衡(P>0.05),并且其等位基因频率在麻风病组和对照组间的差异具有统计学意义(P<0.05)。结论 C13orf31基因单核苷酸多态性位点rs3764147和rs10507522与中国彝族人群麻风病相关。

Objective To investigate the eorelation between the single nucleotide polymorphisms（SNPs）of C13orf31 gene and leprosy in Yi population. Methods The SNPs of C13orf31 gene（rs3764147,rs10507522）in 300 leprosy patients of Yi population and 300 ethnic matched healthy controls were genotyped by SNaP shot. Results The genotype frequencies of these two SNPs were in match with Hardy-Weinberg equilibrium（ HWE ） （ P 〉 0.05 ）. The allele frequencies of rs3764147 and rs10507522 in the leprosy patients were significantly different from those of the control group（ P 〈 0.05 ）. Conclusion rs3764147 and rs10507522 of C13orf31 gene are related to leprosy in Chinese Yi population.