盐酸坦索罗辛与非那雄胺联合应用于前列腺增生术后患者的临床研究

A clinical study on the combination of tamsulosin and finasteride in treating patients with prostatic hyperplasia after TURP surgery

目的探讨经尿道前列腺电切术(TURP)后坦索罗辛联合非那雄胺与单独应用盐酸坦索罗辛、非那雄胺对前列腺增生症(BPH)患者的影响。方法选择我院2010年1月至2011年6月行TURP的120例BPH患者为研究对象,按随机数字表法分为A组(术后应用盐酸坦索罗辛)40例、B组(术后应用非那雄胺)40例、C组(术后盐酸坦索罗辛与非那雄胺联合应用)40例。分别评价各组患者治疗前与治疗后6个月的国际前列腺症状评分(IPSS)、最大尿流率(MFR)、前列腺体积。结果三组治疗前后各项指标比较,差异有统计学意义(P<0.05);治疗后各项指标比较,A组与B组之间差异无统计学意义(P>0.05),C组与A、B组之间比较差异有统计学意义(P<0.05)。结论 TURP术后联合应用盐酸坦索罗辛、非那雄胺可明显改善BPH患者的临床症状,其效果优于单独应用盐酸坦索罗辛、非那雄胺,治疗更为彻底。

Objective To explore the effect of the combination of tamsulosin and finasteride or a drug alone on patients with benign prostatic hyperplasia after transurethral resection of the prostate （TURP）. Methods One hundred twenty patients who underwent TURP surgery in our hospital from January 2010 to June 2011 were randomly divided into group A （tamsulosin alone） , group B （finasteride alone） ,and group C（ combination of tamsulosin and finasteride）. Each group had 40 cases. The parameters such as international prostate symptom score（ IPSS）, maximum urinary flow rate （MFR）and prostate volume were determined in all patients before and 6 months after treatment. Results The parameters were statistically significant before and after treatment in all three groups （P〈 0. 05）. No significant difference in the parameters was found between group A and group B, but significant difference was discovered between group C and group A or group C and group（ P〈0. 05 ）. Conclusions Tamsulosin or finasteride can improve the clinical symptoms of benign prostatic hyperplasia after TURP surgery. Combination of the two drugs has a better effect than a drug alone.