缬沙坦治疗小儿肾病综合征27例血、尿蛋白观察

Effect of Valsartan in children with nephrotic syndrome

目的:探讨缬沙坦对肾病综合征患儿尿蛋白及血浆白蛋白的影响。方法:将54例肾病综合征患儿随机分为卡托普利组和缬沙坦组,两组患儿均给予糖皮质激素治疗、利尿治疗、抗凝治疗,并分别给予卡托普利、缬沙坦治疗,观察比较两组患儿在治疗2周和2个月后的尿蛋白和血浆白蛋白水平及不良反应。结果:两组患儿治疗2个月后尿蛋白转阴和血浆白蛋白升高有显著性差异(P<0.05)。结论:缬沙坦治疗小儿肾病综合征疗效明显,不良反应较轻。

Objective To study the effect of Valsartan on proteinuria and serum albumin in children with nephrotic syndrome. Methods.. 54 patients were divided into captopril group and Valsartan group, captopril and valsartan were administered respectively. All the other treatments （including steroids, diuretics, anticoagulation, etc） were the same in the two groups, Comparison of proteinuria, serum albumin and adverse reactions in the two groups after treatment two weeks and two months. Results ：There were marked differences on the patients proteinuria and serum albumin between the two groups after treatment two months. Conclusion： Our dates showed that Valsartan has definite effects in children with nephrotic syndrome and it is safe for children, so it is worthy of being widely administered for children with nephritic syndrome.