糖化血红蛋白和内皮素检测在急性脑梗死中的应用

The application of glycated hemoglobin and endothelin detection in patients with acute cerebral infarction

目的通过检测伴有血糖升高的急性脑梗死患者体内糖化血红蛋白(HbA1c)和内皮素(ET)值,探讨HbA1c和ET含量变化与急性脑梗死的关系及其临床意义。方法选择159例伴有血糖升高的急性脑梗死患者与63例健康成年人,分别采用离子交换高效液相色谱法(HPLC)及放射免疫分析法检测血液中HbA1c和ET值,并根据HbA1c检测结果将患者分为HbA1c升高组和HbA1c正常组,进行数据分析。结果患者组HbA1c和ET检测结果为(7.92±1.27)%、(81.0±11.1)pg/mL,对照组HbA1c和ET检测结果为(5.17±0.58)%、(48.0±8.2)pg/mL,两组比较差异有统计学意义(P<0.05)。所有患者中HbA1c升高患者较HbA1c正常患者病情重,愈后差,两组比较也有明显差异。结论监测急性脑梗死患者体内HbA1c和ET变化有助于患者病情诊断及预后分析。

Objective To investigate the expression of glycated hemoglobin （HbAlc） and endothelin （ET） content in the patients with high fasting blood-glucose acute cerebral infarction （ACI） and explore the clinical significance of the po- tential changes. Methods In samples from 159 cases of patients and 63 healthy controls, the expression of HbAlc and ET content were detected using ion-exchange high performance liquid chromatography （HPLC） and radiation immunoas- say; And according to the HbAle results, all patients were divided into HbAle rise group （36.2%） and the nor- mal group （〈6.2%）. Results In the group of patients HbAIe and ET results were （7.92±1.27）%, （81.0±11.1） pg/mL, compared with controls （5.17＋0.58）%, （48.0±8.2） pg/mL, with significant differences between the two groups （P 〈 0.05）. All of the patients, compared with patients had normal HbAlc （〈6.2%）, those patients with HbAlc rise （〉6.2%） were in a bad way. Prognosis is poor, two groups of comparisons also have obvious difference. Conclusion Monitoring pa- tients HbAlc and ET might be helpful for early diagnosis and prognosis.