心绞痛患者血清sLOX-1含量与冠状动脉病变危险分数相关性研究

Plasma soluble LOX-1 level is associated with jeopardy score of coronary artery lesion in angina patients

目的检测心绞痛患者血清可溶性血凝素样氧化低密度脂蛋白受体-1(sLOX-1)的浓度,选择性冠脉造影评估冠状动脉病变的危险分数,分析血清sLOX-1水平与危险分数的相关性。方法实验分组:心绞痛组,经冠脉造影证实有明显冠脉狭窄的心绞痛患者43例;对照组,经临床检查及冠脉造影排除冠心病的患者15例。两组患者均采集外周血,测定血清sLOX-1浓度。冠脉病变情况以Califf介绍的危险分数进行评价。结果心绞痛患者尤其是不稳定型心绞痛患者血清中sLOX-1浓度均明显增高(P<0.01),与危险分数呈明显正相关(P<0.01)。结论血清sL-OX-1浓度与冠状动脉病变危险分数密切相关,对评估冠状动脉病变的程度和冠心病患者病情监测可能具有重要的临床价值。

Objective To investigate the level of serum soluble lectin - like oxidized low - density lipoprotein receptor - 1 （ sLOX - 1 ）, the jeopardy score of coronary artery lesion by angiography , and their correlation in patients with unstable angina （UA） or stable angina （SA）. Methods Twenty - six patients with SA, 25 patients with UA and 15 patients excluding coronary heart disease were studied. Blood samples were collected and the level of sLOX - 1 was measured by ELISA. The jeopardy score for coronary artery lesion was evaluated, according to the method by Califf. Results The level of serum sLOX - 1 in angina patients, especially in UA patients was higher than that in control group （ P 〈 0.01 ） , and showed a positive correlation with jeopardy score （ P 〈 0. 01 ）. Conclusion Serum sLOX - 1 level is closely correlated with the jeopardy score of coronary artery lesion. Combined with coronary angiography, the detection of the level of sLOX - 1 may better describe the lesion of coronary artery, and may better evaluate the prognosis of coronary heart disease.