中药现代化与超临界流体萃取的应用

THE MODERNIZATION OF TRADITIONAL CHINESE MEDICINES AND THE APPLICATION OF NEW TECHNOLOGY OF SUPERCRITICAL FLUID EXTRACTION

论述了超临界流体萃取技术在中药开发及产业化中应用的优越性 :萃取能力强、提取率高、有效成分高度富集 ;操作温度低 ,有效成分不被破坏 ;提取时间快、生产周期短 ;操作参数容易控制 ,有效成分及产品质量稳定 ;超临界 CO2 具有灭菌作用 ;应用于药物分析 ,是一种高效的分析手段 ,能客观地反应中药有效成分的真实含量 ;该技术不仅工艺上优越 ,质量标准容易控制 ,其萃取物药理、临床效果能够保证或更好 ;流程简单 ,操作方便 ,节省劳动力和有机溶剂 ,避免易燃易爆的危险 ,减少三废污染 ,是一种集提取、分离、浓缩为一体的高新技术。结合典型的研究开发实例 ,论述了超临界流体萃取技术应用于中药现代化可划分为如下几个方面 :中药有效成分或中间原料的提取分离 ;中药化学成分研究 (即植物化学范畴 ) ;名优中成药生产工艺改革或二次开发 ;单方或复方中药新药的研究与开发 ;中药质量标准的制定 ;提出了如何应用超临界流体萃取技术进行中药现代化及其应用前景。

WT5,5”BZ] In this paper,the situation of the industrialization,the countermeasure of development of traditional Chinese medicines and the necessity of applying the new technology were summarily accounted.The superiorities of applying supercritical fluid extraction(SFE)to the exploitation and industricalization of traditional Chinese medicines were also discussed.The application of SFE to the modernization of traditional Chinese medicines could be divided several ways in combination with the typical cases.Meanwhile how to apply SFE to the modernization of traditional Chinese medicines and the applied prospects were advanced.