2Bellamy N. Pain assessment in osteoarthritis: experience with the WOMAC osteoarthritis index. Semin Arthritis Rheumatism, 1989, 18(Suppl2) : 14-17.
3Homandberg GA, Umadi V, Kang H, et al. High molecular weight hyaluronan promotes of IL-1 beta-damaged explants from both young and old bovines. Osteoarthritis Cartilage,2003,11 (3) : 177-186.
9Wang CT,Lin YT,Chiang BL,et al. High molecular weight hyaluronic acid down-regulates the gene expression of os- teoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis. Osteoarthr Cartil, 2006, 14: 1237-1247.
2Goldring MB, Birkhead J, Sandell LJ, et al. Interleukin-1 suppresses expression of cartilage-specific types Ⅱ and Ⅲ collagens and increases types Ⅰ and Ⅲ collagens in human chondrocytes. J Clin Invest, 1988, 82: 2026-2037.
3Goldring MB, Krane SM. Modulation by recombinant inteleukin- 1 of synthesis of types Ⅰ and Ⅲ collagens and associated procollagen mRNA levels in culture human cells. J Biol Chem, 1987, 262: 16724-16728.
4Quarto R, Dozin B, Bonaldo P, et al. Type Ⅵ collagen expression is upregulated in the early events of chondrocyte differentiation. Development, 1993, 117: 245-251.
5Dingle JT, Homer A, Shield M. The sensitivity of synthesis of human cartilage matrix to inhibition by IL-1 suggests a mechanism for the development of osteoarthritis. Cell Biochem Funct, 1991, 9: 99-102.
6Kikuchi T, Denda S, Yamaguchi T. Effect of sodium hyaluronate (SL-1010) on glycosaminoglycan synthesis and release in rabbit articular cartilage. Jpn Pharcol Ther. 1993, 127:157-163.
7Yasui T, Akatsuka M, TobeRo K, et al. The effect of hyaluronan on interleukin-1a-induced prostaglandin E2 production in human osteoarthritic synovial cells. Agents Actions, 1992, 37: 155-156.
8Tobetto K, Yasui T, Ando T, et al. Inhibitory effects of hyaluronan on [14C] arachidonic acid release from labeled human synovial fibroblasts. Arthritis Jpn J Pharmacol, 1992, 60: 79-84.
9Pelletier JP, Martel-Pelletier J. Evidence for the involvement of interleukin-1 in human osteoarthritie cartilage degradation., protective effect of NSAID. J Rheumatol Suppl, 1959, 15: 19-27.
10Kobayashi M, Squires GR, Mousa A, et al. Role of interleukin- 1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage. Arthritis Rheum, 2005, 52: 128-135.
7Hawker GA. The challenge of pain for patients with OA.HSS J.2012;8(1 ): 42-44.
8Cross M, Smith E, Hoy D, et al. The global burden of hip an knee osteoarthritis: estimates from the Global Burden of Disease 2010 study.Ann Rheum Dis.2014;73(7):1323-1330.
9Scott D, Kowalczyk A. Osteoarthritis of the knee. Clinical evidence.2007: 09:1121.
10Permuy M, Guede D, Lbpez-PeSa M, et al. Effects of glucosamine and risedronate alone or in combination in an experimental rabbit model of osteoarthritis.BMC Vet Res. 2014;10:97.
