磷酸肌醇家族与细胞功能

PHOSPHOINOSITIDES AND CELLULAR EVENTS

磷酸肌醇具有信号前体的作用 ,在激动剂作用下可产生第二信使。近年研究表明磷酸肌醇家族成员本身也可作为脂质第二信使将效应器蛋白聚集于特定膜区以调控它们的组装或活性。磷酸肌醇与蛋白的结合主要依赖于PH、FYVE及PTB结构域。磷酸肌醇家族成员参与许多细胞活动诸如离子转运 ,膜泡运输 ,信号转导 ,细胞骨架再组装和核基因调控。

Signaling roles for phosphoinostides that function as precursors to generate second messengers upon agonist stimulation have been well characterized. Recent work has revealed that phosphoinositides can themselves serve as lipid second messengers to recruit their effector proteins to spatially localized membranes and regulate their assembly or activities. The interactions of phosphoinositides with proteins depend on pleckstrin homology(PH) domains, FYVE domains and phosphotyrosine-binding(PTB) domains.Cellular events in which phosphoinositides have been implicated include ion transport, membrane trafficking, signal transduction, cytoskeletal organization and nuclear gene regulation.