摘要
本课题依据"β-淀粉样蛋白级联假说",使用脑立体定位仪确定大鼠单侧海马Ca1区的颅骨投影位置,注射定量Aβ1-40聚合片段,从而复制得到AD动物模型。应用Morris水迷宫验证造模后和治疗后AD大鼠学习记忆功能的改变,从而推断大鼠海马和外海马损伤程度验证经药物治疗的效果,为试验结论提供准确的行为学依据。
This subject is based on the ＂β -amyloid cascade hypothesis＂ , using stereotaxic instrument to determine the hip- pocampus of rats with unilateral Cal skull projection position, the injection of quantitative Aβ1 -40 aggregation fragment to repli- cate AD animal models. Morris water maze verify the modeling and learning and memory function in AD rats after treatment change, to infer the rat hippocampus and outside the degree of hippocampus damage to verify the effect of the medication, to provide accurate behavior -based test conclusions.
出处
《黑龙江科学》
2013年第1期51-54,共4页
Heilongjiang Science
