不同剂量石膏配伍的麻杏石甘汤治疗哮喘34例临床观察

Clinical Observation on the Treatment of 34 Asthma Patients through Maxinshigan Decoction of Different Doses of Gypsum Compatibility

目的:观察不同剂量石膏配伍的麻杏石甘汤治疗热哮型支气管哮喘临床疗效。方法:把符合入选条件的68例患者随机分成治疗组和对照组各34例,治疗组予麻杏石甘汤(石膏四倍于麻黄),对照组予麻杏石甘汤(石膏三倍于麻黄),1天2次口服,2组均以3周为1疗程,疗程结束后,评价2组患者的临床疗效,治疗前后第1秒用力呼气量(FEV1)、用力肺活量(FVC)及最大呼气流速(PEFR)等肺功能指标,血清免疫球蛋白IgE、组胺、白三烯C4(LTC4)改善情况。结果:治疗组有效率为94.12%,对照组有效率为82.35%,治疗组明显优于对照组(P<0.05);2组肺功能,血清IgE、组胺、LTC4与治疗前比较差异均有显著性(P<0.05),且治疗组优于对照组(P<0.05)。结论:2组均有较好的临床疗效,显著改善患者肺功能及明显降低了血清中的IgE、组胺、LTC4,且治疗组优于对照组。

Objective:To observe the clinical effect of Maxinshigan Decoction of different doses of gypsum compatibility on the treatment of heat asthma patients.Methods:68 patients were randomly divided into a treatment group and a control group,34 patients per group.The treatment group were treated with Maxinshigan Decoction(gypsum four times in ephedra) while the control group were given Maxinshigan Decoction(gypsum three times in ephedra),twice daily orally.Three weeks was a course of treatment.The clinical efficacy,one second forced expiratory volume(FEV1),forced vital capacity(FVC) and peak expiratory flow rate(PEFR) lung function index of the patients in the two groups were evaluated before and after the treatment,and the serum immunoglobulin IgE,histamine,leukotriene C4(LTC4) of the patients improved.Results:The effective rate of the treatment group was 94.12% while that of thecontrol group was 82.35%.The treatment group was significantly better than the control group(P<0.05).The lung function,serum IgE,histamine,LTC4 of the patients showed significance(P<0.05),comparing the differences before and after the treatment.The treatment group was than the control group(P<0.05).Conclusion:Maxinshigan Decoction of different doses of gypsum compatibility has a better clinical effect,significantly improving the patients' lung function and reducing the IgE,histamine,LTC4 in their serum and the treatment group is better than the control group.