降钙素基因相关肽在哮喘豚鼠内脏传入系统的定量分析

QUANTITATIVE ANALYSIS OF CALCITONIN GENE RELATED PEPTIDE LEVELS IN THE VISCERAL AFFERENT SYSTEM OF THE ASTHMATIC GUINEA PIG

本文应用放射免疫分析方法研究了实验性哮喘豚鼠与下呼吸道有关的内脏传入系统内降钙素基因相关肽含量的变化 ,藉以探讨降钙素基因相关肽在哮喘发病时的作用机制。结果表明 ,哮喘豚鼠与下呼吸道有关的内脏传入系统 (结状神经节、C7～T5 节段脊神经节和脊髓后角、孤束核等处 )中的降钙素基因相关肽含量明显高于各对照组 ( P<0 .0 5)。本研究提示 ,下呼吸道和肺的内脏传入成分中的降钙素基因相关肽可能参与哮喘发病的病理生理过程。

The calcitonin gene related peptide (CGRP) levels in the visceral afferent system of asthmatic guinea pigs were measured by means of radioimmunoassay. The results showed that CGRP levels in the primary afferent system (nodose ganglia, C 7～T 5 spinal ganglia, dorsal horn of C 7～T 5 spinal cord and solitary nucleus) were much higher than those in the normal control group(P<0.05). These data indicated that CGRP in the primary afferent system might be involved in the pathogenesis of asthma.