胸腺肽α1对气管切开老年重症肺部感染的预防作用

Preventive effect of thymic peptide α1 on severe pulmonary infection correlated to trachea incision in senile patients

目的观察胸腺肽α1对气管切开老年重症肺部感染的预防作用。方法 40例气管切开患者随机分为治疗组(24例)和对照组(16例)。治疗组在常规治疗基础上给予1.6mg胸腺肽α1皮下注射,每日1次,连用1周,再改为每周2次,连用3周。对照组仅给予常规治疗。观察两组患者肺部感染的发生率以及治疗前后白细胞(WBC)、C-反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-ɑ(TNF(-ɑ))及抗炎细胞因子变化。结果治疗组痰培养结果明显低于对照组;WBC、CRP、IL-6、TNF(-ɑ)显著低于对照组(P<0.01)。结论胸腺肽α1对气管切开的老年重症肺部感染有一定防治作用,能降低WBC、CRP、IL-6炎性因子水平,增强老年患者抗感染能力,改善其预后。

Objective To observe preventive effect of thymic peptideα1 on severe pulmonary infection correlated to trachea incision in senile patients. Methods Forty senile patients post-trachea incision were randomly divided to treatment group（n=24）and control group （n=16）. Thymic peptideα1 was administered subcutaneously injected,1.6 mg daily for one week,than taping to twice a week for two weeks,in addition to conventional therapy. Control group were treated with only conventional therapy. The incidence of pulmonary infection and the variation of white blood cells （WBC）,C-reactive protein （CRP）,interleukin-6 （IL-6）,tumor necrosis factor -ɑ （TNF （-ɑ））,prior and post treatment,were collected. Results The occurrence of pulmonary infection,dual infection or combined infections were significantly lower in treatment group. Furthermore,the level of WBC,CRP,IL-6 and TNF（-ɑ） decrement was marked than that in control group. There were significant differences between two groups （P 0.01）. Conclusions There was preventive and therapeutic effect for thymic peptideα1 to severe pulmonary infection in senile patients. The level of WBC,CRP,IL-6 and other inflammatory factors was lowered. It was helpful for senile patients in strengthening ability to anti-infection,and improving prognosis.