肝硬化门静脉高压性胃病935例临床分析

Clinical analysis of portal hypertensive gastropathy in 935 patients with liver cirrhosis

目的了解肝硬化门静脉高压性胃病(PHG)与肝功能分级、食管胃静脉曲张及消化性溃疡、上消化道出血之间的关系。方法对935例合并PHG的肝硬化患者常规胃镜检查,对可能影响PHG的各种因素进行回顾性分析。结果在935例肝硬化PHG患者中,PHG严重程度与肝功能级别明显相关,差异有统计学意义(P<0.001),792例(84.7%)患者合并食管胃静脉曲张,且随着曲张程度的加重,PHG程度也增加。重度PHG患者消化性溃疡和上消化道出血的比例大于轻度PHG患者。结论随着肝功能分级及食管胃静脉曲张程度的加重,肝硬化PHG严重程度也逐渐加重。

Objective To explore the relationship between portal hypertensive gastropathy （PHG）and comorbid conditions in patients with liver cirrhosis. Methods Retrospective data of 935 PHG patients underwent endoscopy was collected and analyzed. Results The Child-Pugh class was markedly related to the severity of PHG （P0.001） in 935 patients. There was a significantly positive correlation between liver function and gastroesophageal varices. Seven hundred and ninety -two cases accompanied by gastroesophageal varices. Peptic ulcer and upper gastrointestinal bleeding in severe PHG was higher than those with mild PHG. Conclusions The incidence and severity of PHG are positively related to the liver function and gastroesophageal varices.