2Lee Y J, Han S B, Nam S Y, et al. Inflammation andAlzheimer * s Disease [ J]. Arch Pharm Res, 2010, 33. 450 .(10):1539 -1556.
3Surh Y J,Kundu J K,Li M H,et al. Role of Nrf 2 - media-ted heme oxygenase — 1 upregulation in adaptive survivalresponse to nitrosative stress[ J]. Arch Pharm Res,2009,32(8) :1163 -1176.
4Kanninen K,Heikkinen R,Malm T,et al. Intrahippocam-pal injection of a lentiviral vector expressing Nrf 2 im-proves spatial learning in a mouse model of Alzheimer ’ sdisease[ J]. Proc Natl Acad Sci U S A,2009,106(38):16505 - 16510.
5Takeuhi H, Jin S, Wang J,et al. Tumor necrosis factor -alpha induces neurotoxicity via glutamate release fromhemichannels of activated microglia in an autocrine man-ner[J]. J Biol Chem,2006,281 (30) :21362 - 21368.
6Bordji K,Becerril - Ortega J,Nicole 0,et al. Activation ofextrasynaptic, but not synaptic,NMDA receptors modifiesamyloid precursor protein expression pattern and increasesamyloid - p production [ J]. J Neurosci,2010,30 ( 47 ):15927 - 15942.
7Wilkinson K,E L Khoury J. Microglial scavenger receptorsand their roles in the pathogenesis of Alzheimer ’ s disease[J]. Int J Alzheimers Dis ,2012 ,2012 :489456.
8El Khoury J,Toft M,Hickman S E,et al. Ccr 2 deficiencyimpairs microglial accumulation and accelerates progres-sion of Alzheimer 一 like disease[ J]. Nat Med,2007 ,13 ,(4):432 — 438.
9Weiner H L,Frenkel D. Immunology and immunotherapyof Alzheimer’ s disease [ J]. Nature Rev Immunol,2006,6 (5) :404-416.
10Taykor D L, Jones F,Kubota E S,et al. Stimulation of mi-croglial metabotropic glutamate receptor mGlu2 triggerstumor necrosis factor alpha - induced neurotoxicity inconcert with microglial - derived Fas ligand [ J]. J Neu-rosci ,2005 ,25( 11) :2952 - 2964.
二级参考文献12
1Lynch M& The multifaceted profile of activated microglia [J]. Mol Neurobiol, 2009, 40(2):139-156.
2Brent Cameron, Gary E. Landreth. inflammation, microglia, and alzheimer's disease[J]. Neur Dis ,2010, 37(3): 503-509.
3Landreth GE, Reed-Geaghan EG. Toll-like receptors in Alzheimer's disease[J]. Curr Top Microbiol Immunol, 2009, 336: 137-153.
4Neumann H, Takahashi K. Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis[J]. J Neuroimmunol, 2007, 184(1/2): 92-99.
5Walker DG, Dalsing-Hernandez JE, Campbell NA, et al. Decreased expression of CD200 and CD200 receptor in Alzheimer's disease: a potential mechanism leading to chronic inflammation [J]. Exp Neurol,2009, 215(1): 5-19.
6Piazza A, Lynch MA. Neuroinflammatory changes increase the impact of stressors on neuronal function [J]. Biochem Soc Trans, 2009, 37(Pt 1): 303-307.
7El Khoury J, Toft M, Hickman SE, et al. Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease[J]. Nat Med, 2007, 13(4): 432- 438.
8Jimenez S, Baglietto Vargas D, Caballero C, et al. Inflammatory response in the hippocampus of PS1M146I/ APP751SL mouse model of Alzheimer's disease: agedependent switch in the microglial phenotype from alternative to classic [J]. J Neurosci, 2008, 28(45): 11650- 11661.
9Streit WJ, Miller KR, Lopes KO, et al. Microglial degeneration in the aging brain-bad news for neurons? [J]. Front Biosci, 2008, 13: 3423-3438.
10Meyer Luehmann Rapid appearance M, Spires Jones TL, and local toxicity Parada C, et al. of amyloid-beta plaques in a mouse model of Alzheimer's disease [J]. Nature, 2008, 451(7179):720-724.