中药复方有效成分组相关研究方法的研究进展

Progress of research methods on active ingredient group of Chinese herbal formula

中药复方是中医学中的宝贵财富,多成分、多靶点是其优势和特色所在。但由于中药复方成分复杂,作用机理不清,量-效关系缺乏科学的数据支持,严重阻碍了中医药的现代化和国际化进程。中药复方有效成分组是指中药复方中与该复方临床治疗目的密切相关的所有药理活性成分。随着有效成分组概念的提出,中药复方的有效成分组研究日益受到人们的关注。本文对中药复方有效成分组的基本原理和近几年开展的相关研究方法进行了综述,主要介绍了化合物群分析法,指纹图谱分析,药代动力学,高通量药物筛选等技术在中药复方有效成分组研究中的应用,这不仅有助于推动民族药物的继承和发展,为新药开发提供思路和技术上的参考,同时也有助于促进中医药现代化并最终走向世界。

Chinese herbal formula is valuable property of traditional Chinese medicine,multi-component and multi-target are the advantages and features.However,due to the complex ingredients of Chinese herbal formula,mechanism of action is unclear and the dose-effect relationships lack the scientific data to support,all these seriously hampers the process of modernization and internationalization of traditional Chinese medicine.Active ingredient group of Chinese herbal formula means all the pharmacologically active ingredient closely related to the clinical therapeutic purposes.With the concept of the active ingredient group of traditional Chinese medicine proposed,this field has become an increasing concern.The article reviewed the basic principles and research in recent years,mainly introducing the application of the compound group analysis,fingerprint analysis,drug metabolism and pharmacokinetics and high-throughput screening technology in the study of active ingredient group.This not only helps to provide ideas and technical reference for the development of new drugs by promoting the inheritance and development of the national drug,while also contribute to the modernization of Chinese medicine and process to the world.