成人社区获得性下呼吸道感染患者的病原菌检测及耐药性分析

Detection of pathogens causing adult community-acquired lower respiratory tract infections and analysis of drug resistance

目的探讨成人社区获得性下呼吸道感染患者的病原菌检测及耐药性,为其诊断与治疗提供依据。方法选取2011年1-12月于医院进行治疗的108例成人社区获得性下呼吸道感染患者为研究对象,对其痰标本进行检测,对检出病原菌分布及耐药性进行研究分析。结果 108例患者共检出104株病原菌,其中革兰阴性菌71株占68.27%,革兰阳性菌28株占26.92%,真菌5株占4.81%,革兰阴性菌的检出率明显高于其他菌株,而耐药率方面各菌株也存在一定差异。结论成人社区获得性下呼吸道感染患者的病原菌仍以革兰阴性菌为主,且耐药性也较为突出,在诊断及用药过程中应给予重视。

OBJECTIVE To explore the detection of pathogens causing adult community-acquired lower respiratory tract infections and analyze the drug resistance so as to provide basis for the diagnosis and treatment. METHODS A total of 108 patients with adult community-acquired lower respiratory tract infections,who were treated in the hospital from Jan 2011 to Dec 2011, were chosen as the research objects. The sputum samples were taken for testing. Then the pathogens distribution and drug resistance were detected and taken for research and analysis. RESULTS A total of 104 strains of pathogens were isolated from 108 patients, including 71 （68.27%） strains of gram-negative bacteria, 28 （26.92 %） strains of gram-positive bacteria , and 5 （4.82 %） strains of fungi. The detection rate of the gram-negative bacteria was significantly higher than that of other strains, and all the strains varied in the drug resistance rate to certain extent. CONCLUSION The gram-negative bacteria are the main pathogens causing the adult community-acquired lower respiratory tract infections, the drug resistance is serious, which the great attention should be paid to during the diagnosis and treatment.