血培养标本病原菌分布及耐药性分析

Distribution of pathogens cultured from blood specimens and analysis of drug resistance

目的了解医院血培养病原菌的分布及常见病原菌的耐药特点,为临床用药提供依据。方法回顾性统计分析2008年1月-2010年12月送检的血标本分离的病原菌分布和耐药性。结果 3年共分离出病原菌579株,检出阳性率为13.1%,主要病原菌为凝固酶阴性葡萄球菌169株占29.2%、大肠埃希菌105株占18.1%、肺炎克雷伯菌70株占12.1%、金黄色葡萄球菌55株占9.5%;利奈唑胺、替考拉宁和万古霉素对革兰阳性菌高度敏感,亚胺培南对大肠埃希菌和肺炎克雷伯菌高度敏感。结论及时了解血培养结果可以为临床抗菌治疗提供依据,对提高治愈率有重要的临床意义。

OBJECTIVE To investigate the distribution and characteristics of blood culture pathogens so as to provide basis for clinical medication. METHODS A retrospective analysis of the distribution and antibiotics resistance of pathogens isolated from blood culture was performed from Jan 2008 to Dec 2010. RESULTS A total of 579 strains of pathogens were isolated during the three years with the detection rate of 13.1 %. The most common pathogenic bacteria were coagulase-negative Staphylococcus （169 strains, 29.2 %）, Escherichia coli （105 strains, 18.1%）, Klebsiella pneumoniae （ 70 strains, 12.1 %） and Staphylococcus aureus （55 strains, 9.5 %）. The gram-positive bacteria were highly susceptible to linezolid, teicoplanin,and vancomycin, and E. coli and K. pneumoniae were highly susceptible to imipenem. CONCLUSION It is of great significance in improving the cure rate to understand the blood culture result in a timely manner so as to provide basis for the clinical antibiotics therapy.