摘要
介孔二氧化硅纳米粒(MSNs)是一种新型无机纳米材料,因具有独特的网状孔道结构、巨大的比表面积、孔径分布窄且可调节及易于表面修饰等特性,已用于药物控释系统的研究。MSNs载体的药物负载量与其介孔容积相关,表面经修饰后可实现药物的控释和靶向传递。然而,随着MSNs载体与人体接触的机会和时间日益增加,其安全性也受到广泛关注。本文综合近10年来国内外的相关文献,归纳了MSNs在递药系统中的应用,并分析了其生物安全性的影响因素。
Mesoporous silica nanoparticles （MSNs） are novel multifunctional inorganic nanosized materials,which have been extensively applied to develop the controlled-release drug delivery systems owing to their unique pore structures, large specific surface area, narrow and adjustable pore size distribution as well as ease of surface modification,The drug loading of MSNs is dependent on their mesopore volume. After surface modification, MSNs have the properties of controlled-release and targeted delivery. Meanwhile, the biological safety of MSNs comes in the spotlight with morechances and more time that the public expose trader them. This paper reviews the application of MSNs to drug delivery system through consulting related literatures at home and abroad in recent decade, the influence factors on their biologicalsafety are also systematically summarized.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2013年第1期81-87,共7页
Chinese Journal of Pharmaceuticals
关键词
介孔二氧化硅
载体
控释
靶向传递
生物安全性
综述
mesoporous silica
carrier
controlled-release
targeted delivery
biological safety
review
