摘要
以3,4,5-三甲氧基苯乙酸为原料,二甲苯为溶剂,经缩合环合一锅法合成3,4-二氢-6,7-二甲氧基-1-[2-(3,4,5-三甲氧基苯基)乙基]异喹啉,再经碘甲烷甲基化、硼氢化钾还原制得标题化合物,总收率约63%(以3,4,5-三甲氧基苯乙酸计)。
Abstract：5＇-Methoxylaudanosine was synthesized as the key intermediate of Mivacurium chloride from 3,4,5-trimethoxyl acetic acid by condensation with 2-（3,4-dimethoxyphenyl） ethanamine and cyclocondensation with phosphorus triehloride in dry xylene in one-pot synthesis to give 3,4-dihydro -6,7- dimethoxy-1 - [ 2- （ 3,4,5-trimethoxyphenyl ） ethyl ] isoquinoline hydrochloride, which reacted with iodomethane, followed by reduction with KBH4. The overall yield is 63.3% （ based on 2-（ 3,4,5-trimethoxyphenyl） acetic acid）. Key words： 5＇-methoxylaudanosine; mivaeurium chloride; muscular relaxants ; synthesis
出处
《化学试剂》
CAS
CSCD
北大核心
2013年第1期94-96,共3页
Chemical Reagents
基金
2010年度第一批次院级科研课题资助项目(KJY2010-19)
2011江苏省大学生实践创新课题资助项目(CX2011-6)
关键词
5’-甲氧基劳丹素
米库氯铵
肌松药
合成
5＇-methoxylaudanosine
mivaeurium chloride
muscular relaxants
synthesis
