灵芪扶正汤对辐射损伤小鼠的防护作用研究

Research on the protective effect of Lingqifuzheng Decoction in radiation injured mice

目的研究灵芪扶正汤的抗辐射作用。方法采用60 Coγ射线照射造成辐射损伤模型,分别于照射后第3,7,14和25d检测小鼠外周血象,并测定胸腺、脾脏指数,HE染色观察脾脏的病理学变化。结果辐射损伤后小鼠外周血白细胞、红细胞、血小板计数降低,胸腺、脾脏指数下降。与模型组比较,灵芪扶正汤高剂量差异有统计学意义(P<0.05),可促进上述指标的恢复。结论灵芪扶正汤对辐射损伤小鼠的造血系统和免疫系统具有一定的保护作用。

Objective To study the anti-radiation effect of Lingqifuzheng Decoction.Methods Modeling by 60Co gamma-ray,the peripheral blood of mice were detected on the 3,7,14 and 25 days respectively after radiation.The index of thymus and spleen were determined.By HE staining,the pathological changes of the spleen were observed.Results After radiation,the peripheral blood routine was reduced,so was the index of thymus and spleen.Compared with model group,high-dose group of Lingqifuzheng Decoction could accelerate the restoration of recovery of all these indexes with significant difference（P0.05）.Conclusion Lingqifuzheng Decoction had a protective effect on the hematopoietic and immune system in the radiation-injured mice.