中西医结合治疗消化性溃疡78例临床疗效观察

Clinical Effect Observation of Integrated Traditional Chinese and Western Medicine in Treatment of 78 Cases of Patients with Peptic Ulcer

目的:探讨中西医结合治疗H.pylori相关性消化性溃疡的临床疗效。方法:将78例确诊为H.pylori相关性消化性溃疡的患者随机分为对照组和治疗组。其中,对照组38例采用奥美拉唑、枸橼酸铋钾、阿莫西林以及克拉霉素三联疗法治疗,治疗组40例在三联疗法的基础上加用健胃汤进行治疗。4周为1个疗程,两组均治疗1个疗程。结果:两组患者治疗1个疗程后,治疗组临床总有效率达90.00%,对照组临床总有效率达71.05%,两者比较差异有统计学意义(P<0.05),治疗组优于对照组。在治疗的过程中,两组均未出现严重不良反应。结论:中西医结合治疗H.pylori相关性消化性溃疡具有疗效高、无明显副作用、复发率低等优点,值得临床推广应用。

Objective：To observe the clinical effect of integrated traditional chinese and western medicine in treatment of patients with H. pylori related peptic ulcer. Methods ： 78 patients with H. pylori related peptic ulcer were randomly divided into two groups. 38 patients were allocated into control group treated with triple therapy of Omeprazole, bismuth potassium citrate, amoxicillin and clarithromycin, while 40 patients were allocated into treatment group treated with Jianwei Decoction combined with triple therapy. Four weeks is a course of treatment, and both groups were treated for a course of treatment. Results ： After a course of treatment, the total effective rate of treatment group is 90.00%, and the total effective rate of control group is 71. 05%. By chi-square（χ2 ） test, there is significant difference in total effective rate compared control group with treatment group （P〈0.05）, and compared with control group, treatment group has batter clinical effect. In the treament of control group and treatment group, serious adverse clinical symptoms and significant liver and kidney dysfunction did not appear, compared with pre-treatment. Conclusion：There is significant clinical effect of integrated traditional chinese and western medicine in treatment of patients with H. pylori related peptic ulcer, and the treatment protocols is more secure and has low recurrence rate which is worthy of clinical popularization and application.