N末端B型利钠肽原对重症监护病房感染性休克患者预后的预测作用

Predictive Values of N-terminal pro-B-type Natriuretic Peptide in the Prognosis of Patients with Septic Shock in ICU

[目的]探讨N末端B型利钠肽原（NT-proBNP）对重症监护病房感染性休克患者预后的预测作用。[方法]前瞻性记录、观测本院重症监护病房40例感染性休克患者的临床特征，比较不同患者血中NT—proBNP水平。[结果140例患者中有18人死亡，死亡组住院24h时NT-proBNP水平为（240．54-36．7）Pg／rnL，住院48h时NT—proBNP水平为（398．6±40．0）pg／mL，与存活组（22例）住院24h时NT—proBNP水平（149±26．4）pg／mL、住院48h时NT-proBNP水平（150．1±37．0）pg／mL相比差异均有显著性（P〈O．05）。[结论]NT-proBNP能预测重症监护病房感染性休克患者的预后情况。

[Objective] To explore the predictive value of N-terminal pro-B-type natriuretic peptide （NT- Pro BNP） in the prognosis of patients with septic shock in icu. [Methods] Clinical features of 40 patients with septic shock in ICU of our hospital were prospectively recorded and observed. Plasma NT-Pro BNP was compared among different patients. [Results] Among 40 patients, 18 patients died. The level of NT-Pro BNP in death group at 24h and 48h of hospitalization was （240.5±36.7）pg/mL and （398.6±40.0）pg/mL respectively, and there was significant difference between death group and survival group[（149±26.4）pg/mL and （150.1±37.0）pg/mL, respectively]（ P 〈0.05）. [Conclusion] NT-Pro BNP level can predict the prognosis of patients with septic shock patient in ICU.