人再生基因蛋白Ⅳ在晚期胃癌患者血清中的表达及意义

Expression of Human Regenerating Gene Protein IV in Serum of Patients with Advanced Gastric Carcinoma and Its Significance

[目的]探讨人再生基因蛋白Ⅳ（REG1V）在胃癌的诊断和预后判断中的价值。[方法]收集61例晚期胃癌患者及35例同期健康成年人的血清学标本，采用酶联免疫吸附试验（ELISA）定量检测胃癌患者化疗前后及健康者REG1V的水平。同时查阅患者病历资料结合胃癌传统肿瘤标志物癌胚抗原（CEA）、CA199、CA724的水平进行比较。[结果]胃癌纽血清REG1V水平显著高于健康对照组[P〈0．01，5．15（2．14～22．55）ng／mLvs．2．22（0．02～12．29）ng／mL]。在胃癌患者中，有淋巴转移患者的REGIV水平高于无淋巴结转移者（P〈0．05）。REG1V检测胃癌的灵敏度为78．7％，明显高于CEA、CA199、CA724（P〈0．05）。血清REGⅣ水平阳性与阴性患者的总生存期相比较差异无显著性（P〉0．05）。[结论IREGⅣ作为血清标志物对胃癌的诊断具有较高的敏感性和特异性，有一定的诊断价值。

[Objective]To explore the value of human regenerating gene protein IV （REG IV ） in the diagno- sis and prognosis of gastric cancer. [Methods]Serum samples of 61 patients with gastric adenocarcinoma and 35 concurrent healthy controls were collected. ELISA quantitative analysis was used to examine the serum levels of REG IV in patients with gastric cancer before and after chemotherapy and healthy controls. The data of case history combined with the detection of traditional tumor markers carcinoembryonie antigen（CEA）, CA199 and CA724 were compared between two groups. [Results] Serum REG IV level in gastric cancer group was significantly higher than that in healthy control group[ P %0.01, 5. 15（2. 14-22. 55） ng/mL vs. 2. 22（0.02- 12.29）ng/mL]. The level of REG IV in patients with lymph node metastasis of gastric cancer group（ P 〈0. 05）. The sensitivity of REG IV for gastric cancer was 78.7%, which was obviously higher than that of CEA, CA199 and CA724（P%0.05）. There was no significant difference in the overall survival time between patients with negative REG IV and patients with positive REG Ⅳ （ P〉0.05）. [Conclusion]REG IV as serum markers has higher sensitivity and specificity for the diagnosis of gastric cancer, and has a certain diagnostic value.