美沙拉嗪治疗腹泻型肠易激综合征的临床疗效观察

Observation on the Clinical Efficacy of Mesalazine in the Treatment of Diarrhea-type Irritable Bowel Syndrome

[目的]观察美沙拉嗪治疗腹泻型肠易激综合征（IBS）的临床疗效。[方法]选择本院95例腹泻型IBS患者，随机分成两组，治疗组53例，对照组42例，治疗组给关沙拉嗪肠溶片（每次0．5g，每天4次），对照组给予马来酸曲美布汀分散片（每次0．1g，每天3次），治疗28d后，观察两组临床疗效及症状改善情况。[结果]治疗组总有效率为86．8％（45／53），对照组为64．3％（27／42），两组相比较差异有显著性（P〈0．05），治疗组在缓解腹泻方面明显优于对照组。[结论]美沙拉嗪能有效缓解腹泻型IBS患者的多种症状，其中对于腹泻有着显著的改善作用。

[Objective] To observe the clinical efficacy of mesalazine for the treatment of patients with diarrheatype irritable bowel syndrome（IBS）. [Methods] Totally 95 patients with diarrhea-type IBS were randomly divided into treatment group（ n = 53） and control group（ n =42）. The treatment group was given mesalazine slow release tablets（0.5g for once and 4 times daily）. The control group was given trimebutine maleate dispersible tablets（0, lg for once and three times daily）. At 28 days after treatment, clinical efficacy and the improvement of symptoms in two groups were observed. [Results] The total effective rate in the treatment group was 86.8% （45/53）, while that in the control group was 64.3%（27/42）. There was significant difference between two groups（ P %0.05）. The improvement of diarrhea in the treatment group was better than that in the control group. [Conclusion] Mesalazine can effectively alleviate many kinds of symptoms of patients with diarrhea-type IBS, and significantly improve the diarrhea.