摘要
目的比较乙酰螺旋霉素片剂和胶囊剂的体外抗菌作用。方法将乙酰螺旋霉素随机分为片剂组和胶囊组,2组均进行药物体外抗菌实验,测定其对大肠杆菌、金黄色葡萄球菌、枯草芽孢杆菌及绿脓杆菌的最小抑菌浓度(MIC)和最小杀菌浓度(MBC),对2组的抗菌作用进行比较。结果片剂组MIC及MBC值均高于胶囊组,差异均有统计学意义(P<0.05)。结论乙酰螺旋霉素片剂抗菌效果优于胶囊剂,可将片剂作为抗菌作用的最佳剂型。
Objective To compare the antibacterial action of acetylspiramycin tablet and capsule.Methods Acetylspiramycin were randomly divided into tablet group and capsule group,both of the two group did antimicrobial experiment in vitro,and determined the MIC and MBC with escherichia coli,staphylococcus aureus,bacillus subtilis and pseudomonas aeruginosa.Compared the antibacterial action between the two groups.Results The MIC and MBC of tablet group was higher than that of capsule group,the difference was statistically significant（P 0.05）.Conclusion The antibacterial action of acetylspiramycin tablets is better than that of capsule,and tablet can be set as the best dosaga form.
出处
《临床合理用药杂志》
2013年第1期10-11,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
乙酰螺旋霉素
片剂
胶囊
抗菌作用
Acetylspiramycin
Tablet
Capsule
Antibacterial action
