摘要
衰老是导致眼部生物学改变的常见原因，特别对Bruch膜影响更明显。研究发现，Bruch膜随着年龄的增加其功能和结构亦发生异常改变。衰老因素在（age—relatedmaculardegenera—tion，AMD）等黄斑疾病早期阶段的病理改变中起重要作用，随年龄增加，Bruch膜的解剖结构、生理功能、脂类沉积等发生相关变化，这些变化可能是AMD等病变发生、发展的重要原因，对这些影响因素的进一步研究，可以为探索黄斑疾病的病因、病理机制、诊断及治疗提供一定的理论依据。
Aging is a common feature of biological changes in the eye, especially in the Bruch mem- brane. It is recognized that Bruch membrane changes with the increase of age. Aging may be an important e- vent to contribute to the pathogenesis of macular diseases, such as age-related macular degeneration （AMD）. Therefore, this review summarizes the latest concepts about the changes of anatomic structure, physiological function, lipids deposition on Bruch membrane with age, these factors may play an important role in the macular diseases. Further study on these factors will offer new ideas about the etiology, patholo- gy, diagnose and treatment of macular diseases.
出处
《国际眼科纵览》
2012年第6期387-391,共5页
International Review of Ophthalmology
