容积调控性氯通道与晶状体后囊膜混浊发病机制的关系

The relationship between volume-regulated chloride channel and pathogenesis of posterior capsular opacification

后囊膜混浊为白内障摘除术后残留在晶状体囊袋赤道部的晶状体上皮细胞异常增生移行至后囊膜并分化为成纤维细胞所致，其可直接影响患者术后视力及视觉质量。最近研究发现晶状体上皮细胞上表达多种类型的氯通道，其中容积调控性氯通道作为生物体内一类重要的阴离子通道，除了与细胞的容积调节有关，还在细胞增生、移行与分化等过程中起着重要作用，与晶状体后囊膜混浊形成相关。深入了解此通道可为术后晶状体后囊膜混浊的治疗和预防提供新的线索。

Posterior capsular opacification （PCO） is caused by proliferation, migration and epitheli- al-mesenchymal transition （EMT） of residual lens epithelial ceils （LEC） in the equatorial region of capsule after cataract surgery, which influences the recovery of visual acuity and the improvement of visual quality af- ter operation. Recently some researches demonstrate LEC express various types of chloride channels, and chloride channel is one kind of the most important anion channels in an organism that take part in electric ac- tivity, and also have a close relation with cell volume, proliferation, differentiation and migration. This pa- per bases on the newest research in volume-regulated chloride channel and introduce relationship between the pathogenesis of posterior capsular opacification and its molecular construction and physical function in order to provide new clues for future therapy of PCO.