埃索美拉唑联合莫沙比利治疗老年人胃食管反流病疗效观察

Effect of esomeprazole combined with mosapride on outcomes in elderly patients with gastroesophageal reflux disease

目的观察埃索美拉唑联合莫沙比利对老年人胃食管反流病的疗效。方法 52例均经内镜证实的反流性食管炎老年患者随机分为两组,治疗组28例用埃索美拉唑镁肠溶片40 mg,每天1次,莫沙比利5 mg,每天3次;对照组24例用奥美拉唑肠溶胶囊20 mg,每日2次,莫沙比利10 mg,每天3次,分别于治疗后4、8周,观察烧心、反流等症状疗效,并且观察内镜下反流性食管炎程度的变化。结果埃索美拉唑加莫沙比利治疗组用药4周时有效率为71.4%,对照组为45.8%,差异有统计学意义(P<0.05)。用药8周时治疗组临床症状明显好转,有效率为96.4%,明显优于对照组的79.1%(P<0.05)。内镜复查食管黏膜病灶愈合率治疗组明显优于对照组,差异有统计学意义(P<0.05)。结论埃索美拉唑联合莫沙比利是治疗老年人胃食管反流病的有效方法。

Objective To investigate the effect of esomeprazole combined with mosapride on outcomes in elderly patients with gastroesophageal reflux disease（GERD）.Methods All 52 cases of reflux esophagitis in elderly patients confirmed by endoscopy were randomly divided into two groups,28 patients as treatment group were given esomeprazole 40 mg once daily,and mosapride 5 mg,3 times daily;Twenty-four patients as control group were given omeprazole 20 mg twice daily,and mosapride 5 mg,3 times daily.Clinical symptoms such as reflux and heartburn were observed after four and eight weeks espectively,and the degrees of reflux esophagitis were detected by endoscopy.Results After four weeks,efficacy rate was 71.4% in treatment group versus 45.8% in control group（P0.05）.Significant improvements were demonstrated for treatment group compared with control group after eight weeks.The efficacy rate was 96.4% and 79.1% espectively（P0.05）.The heeling rate of injury in mucous memberane of esophagus in endoscopy was higher in the treatment group than that in the control group（P0.05）.Conclusion Esomeprazole combined with mosapride is an effective therapeutic agent for the treatment of GERD in elderly patients.