新疆维吾尔自治区克拉玛依市市区女性乳腺癌危险因素的病例对照研究

Case-control study on the breast cancer risk factors of women in Karamay urban, Xinjian Uygur Autonomous Region

目的探讨新疆维吾尔A治区克拉玛依市市区女性乳腺癌的危险因素。方法用病例对煺研究方法调查129例女性乳腺癌和对应的129名对照者，用Logistic回归模型进行乳腺癌危险因素分（OX=1．423，95％CI=1．160。1．810）、乳腺炎（OR：2．363，95％CI=2．039～3．934）、子宫肌瘤（OR=1．623．95％CI=1．263～2．024）、人工流产（OR=1．723，95％CI=1．143～2．600）、饮酒（OR：1．243。95％CI=1．040～1．483）、精神创伤（OR=2．184，95％CI=1．753—3．025）、长期接触电离辐射（OR=1．374，95％CI=1．152～1．699）；保护因素有初潮年龄增大（OR=0．773，95％CI=0．674—0．956）、累计哺乳时间长（OR=0．672，95％CI=0．480～0．941）、坚持运动（OR=0．572，95％CI=0．391～O．837）。结论以上11个因素为克拉玛依市市区女性乳腺癌重要的影响因素。

Objective To investigate the breast cancer risk factors in women of the Karamay Oilfield. Methods A case control study included 129 breast cancer patients and 129 normal healthy women. The logistic regression model was used for evaluating the breast cancer risk factors. Results The risk factors of breast cancer included a family history of breast cancer （OR = 2.744, 95 % CI = 1.884-4.674）, breast hyperplasia （OR = 1.423, 95 % CI= 1.160-1.810）, mastitis （OR = 2.363, 95 % CI = 2.039-3.934）, uterine fibroids （OR = 1.623, 95 % C1 = 1.263-2.024）, abortion （OR = 1.723, 95 % CI = 1.143-2.600）, drinking （OR = 1.243,95 % C1 = 1.040-1.483）, trauma （OR = 2.184, 95 % CI = 1.753-3.025）, long-term exposure to ionizing radiation （OR = 1.374, 95 % CI = 1.152-1.699）; protective factors inculded increased age at menarche （OR = 0.773, 95 % CI = 0.674-0.956）, cumulative lactation time （OR =0.672, 95 % CI = 0,480-0.941）, adhere to exercise （OR = 0.572, 95 % CI = 0.391-0.837）. Conclusion These 11 factors could be important factors for breast cancer risk in Karamay Oilfield women.