期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

血液透析患者维生素D的横断面调查及相关性分析 被引量：1

下载PDF
导出
摘要 目的调查维持性血液透析患者中25羟维生素D3(25(OH)D3)分布情况,分析血清25(OH)D3水平与多种指标的相关性。方法采用放射免疫分析法统一检测88例维持性血透患者空腹血清25(OH)D3水平(患者检测前停用钙剂或活性维生素D制剂2周)以评估维生素D储备及分布情况,根据血清25(OH)D3水平分为正常、不足、缺乏3组。对血清25(OH)D3水平与患者年龄、透析时间、矿物质代谢指标(血钙、血磷、全段甲状旁腺激素水平)、营养指标(血清白蛋白含量、血红蛋白)的相关性进行多元逐步回归分析。结果 88例患者血清25(OH)D3水平为(20.14±15.78)μg/L。25(OH)D3正常16例(18%),不足31例(35%),缺乏41例(47%)。多元逐步回归分析显示,血清25(OH)D3与透析时间、年龄、PTH具有相关性(β分别为0.522,-0.340,-0.218,P分别为<0.01,0.01,0.05)。结论维持性血液透析特别是透析时间较短的患者维生D缺乏及不足较高,应加强维生素D的补充及加强对患者的教育,以提高其对血液透析并发症的认识。
作者 王萍 刘平
机构地区 江苏省南京市玄武区锁金村社区卫生服务中心 江苏省中西医结合医院
出处 《现代中西医结合杂志》 CAS 2013年第3期288-290,共3页 Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词 血液透析 维生素D 横断面 相关性
分类号 R459.5 [医药卫生—治疗学]
  • 相关文献

参考文献6

  • 1Holick MF. Vitamin D deficiency[J].N Engl J Med,2007,357:266 -281.
  • 2Holick MF, Siris ES, Binkley N, et al. Prevalence of vitamin D inad- equacy among postmenopausal North American women receiving os- teoporosis therapy [ J ]. J Clin Endocrinol Metab, 2005,90 : 3215 - 3224.
  • 3Wolf M, Shah A, Gutierrez O,et al. Vitamin D levels and early mor- tality among incident hemodialysis patients [ J ]. Kidney Int,2007, 72(8) :1004 - 1013.
  • 4Taskapan H,Ersoy FF, Passadakis PS,et al. Severe vitamin D defi- ciency in chronic renal failure patients on peritoneal dialysis [ J ]. Clin Nephrol,2006,66:247 - 255.
  • 5Ravani P, Malberti F,Tripepi G,et al. Vitamin D levels and patient outcome in chronic kidney disease[ J]. Kidney Int,2009,75:8~ - 95.
  • 6Nykjaer A, Dragun D, Wahher D, et al. An endocytic pathway es- sential for renal uptake and activation of thesteroid 25 - (OH) vita- min D3[J]. Ce11,1999,96:507-515.

同被引文献20

  • 1Pilz S,Tomaschitz A, Friedl C, et al. Vitamin D status and mortality in chronic kidney disease [ J ]. Nephrol Dial Transplant, 2011,26 ( 11 ) :3603-3609.
  • 2Querfeld U, Mak RH. Vitamin D deficiency and toxicity in chronic kidney disease : in search of the therapeutic window [ J ]. Pediatr Nephrol,2010,25 (12) :2413-2430.
  • 3Janner M, Ballinari P, Mullis PE, et al. High prevalence of vitamin D deficiency in children and adolescents with type 1 diabetes [ J ]. SwissMed Wkly,2010,140 : w13091.
  • 4Velayoudom-Cephise FL, Larifla L, Donnet JP, et al. Vitamin D defi- ciency, vitamin D receptor gene polymorphisms and cardiovascular risk factors in Caribbean patients with type 2 diabetes [ J ]. Diabetes Metab, 2011,37 ( 6 ) :540-545.
  • 5Reichel H, Deibert B, Schmidt-Gayk H, et al. Calcium metabolism in early chronic renal failure : implications for the pathogenesis of hyper- parathyroidism [ J]. Nephrol Dial Transplant, 1991,6 ( 3 ) : 162-169.
  • 6Tessitore N, Venturi A, Adami S, et al. Relationship between serum vitamin D metabolites and dietary intake of phosphate in patients with early renal failure[ J]. Miner Electrolyte Metab, 1987,13 ( 1 ) : 38-44.
  • 7Ravani P, Malberti F, Tripepi G, et al. Vitamin D levels and patient outcome in chronic kidney disease [ J ]. Kidney Int, 2009,75 ( 1 ) : 88-95.
  • 8Krause R, Schaber-Halstenberg H J, Edenharter G, et al. Vitamin D status and mortality of German hemodialysis patients [ J ]. Anticancer Res,2012,32( 1 ) :391-395.
  • 9Fiedler R, Dorligjav O, Seibert E, et al. Vitamin D deficiency, mor- tality, and hospitalization in hemodialysis patients with or without protein-energy wasting [ J ]. Nephron Clin Pract, 2011,119 ( 3 ) : c220-226.
  • 10Tahrani AA,Ball A,Shepherd L,et al. The prevalence of vitamin D abnormalities in South Asians with type 2 diabetes mellitus in the UK[J]. Int J Clin Praet,2010,64(3) :351-355.

引证文献1

二级引证文献2

现代中西医结合杂志
2013年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部