敷和备化方治疗原发性肝癌介入术后综合征40例

Fuhe Beihua Fang for Postoperative Syndrome of 40 Patients with Primary Liver Cancer after Intervention

目的观察敷和备化方对原发性肝癌介入术后综合征的临床疗效。方法 80例患者随机分为治疗组、对照组各40例。治疗组肝动脉化疗栓塞(TACE)后服用敷和备化方,对照组TACE后不服中药。观察2组治疗前后症状积分的变化,肝功能指标(碱性磷酸酶、门冬氨酸氨基转移酶、丙氨酸氨基转移酶)的变化,行为状态Karnofsky评分分级,肿瘤标志物甲胎蛋白(AFP)的变化等。结果治疗组对发热、恶心呕吐、腹胀、黄疸、胁痛等症状的改善优于对照组(P<0.05),可明显提高患者生活质量(P<0.05),有效减轻肝功能损害(P<0.05),降低AFP含量(P<0.05)。结论敷和备化方治疗原发性肝癌介入术后综合征,能有效改善患者临床症状,降低因肿瘤原因升高的肿瘤标志物AFP含量,改善肝功能指标,提高患者术后的生活质量。

OBJECTIVE To observe the clinical effects of Fuhe Beihua Fang on postoperative syndrome of 40 patients with primary liver cancer after interventional therapy. METHODS 80 cases were randomly divided two groups： control group and treatment group with 40 cases in each. Treatment group was given Fuhe Beihua Fang after undergoing hepatic artery chemo- therapeutic embolism （TACE） ; while control group didn＇t. Then we observed integration changes of symptoms before and af- ter treatment, and indexes of liver function （including alkaline phosphatase, AST and ALT）, Karnofsky score and change of tumor marker AFP. RESULTS Treatment group showed better effects on fever, nausea and vomiting, abdominal distension, jaundice and hypochondriac pain, compared with control group （P〈0.05）, significantly improved patients life quality （P〈 0.05）, relieved impairment of liver function（P〈0.05） and lower ed AFP（P〈0.05）. CONCLUSION Fuhe Beihua Fang can effectively improve clinical symptoms of patients, lower tumor marker AFP caused by carcinoma, improve indexes of liver function and life quality of patients.