美金刚联合小牛血去蛋白提取物治疗老年性痴呆的临床观察

Clinical Observation on the Effect of Memantine Combined with Deproteinized Hemoderivative of Calf Blood on Alzheimer's Disease

目的探讨联合应用美金刚(易倍申)和小牛血去蛋白提取物(鸿源)对老年性痴呆患者认知功能和行为能力的改善作用。方法 92例老年性痴呆患者随机分为两组,治疗组46例采用美金刚与小牛血去蛋白提取物治疗,对照组46例仅采用美金刚治疗。治疗前与治疗12周后评价简易智能精神状态评估量表(MMSE)、日常生活功能量表(ADL)、长谷川痴呆量表(HDS)、韦氏记忆量表(WMS)。结果治疗组治疗后MMSE、ADL、HDS、WMS评分较对照组均有明显改善,差异有统计学意义(P<0.05)。治疗组治疗前后评分亦有显著改善,差异有统计学意义(P<0.05)。结论美金刚和小牛血去蛋白提取物联合治疗对老年性痴呆患者认知、行为能力等均有显著改善作用。

Objective To investigate the effect of combination therpy of memantine and calf blood deproteinized extracts on the cognitive function and behavior capacity of patients with senile dementia. Methods Ninety-two cases of senile dementia patients were randomly divided into two groups. Treatment group： 46 cases, 12 weeks of treatment total, memantine 20 mg oral each day, and received the calf blood deproteinized extract 800 mg with normal saline intravenous infusion of 250 mL per day for two weeks. Control group of 46 patients with memantine 20 mg orally, 12 weeks of treatment as well. Before and after 12 weeks of treatment, the mini mental status assessment scale （MMSE）, activities of daily living scale （ADL）, Hascgawa＇s dementia scale （HDS）, Wechsler＇s Memory Scale（WMS） were evaluated. Results After treatment, the MMSE, ADL, HDS, and WMS scores of the treatment group showed significant improvement compared with the control group, with statistically significant difference （P 〈0.05）. The scores after treatment in the treatment group also significantly improved than those before treatment, with statistically significant difference （P 〈0.05）. Conclusions Combined treatment of memantine and calf blood deproteinized extracts can significantly improve cognition and behavior ability in the senile dementia patients.