急性脑梗死患者纤维蛋白原与D-二聚体水平的变化及其临床意义

Analysis of the changes of fibrinogen and D-dimer in acute cerebral infarction patients

目的探讨纤维蛋白原与D-二聚体在急性脑梗死（ACI）病情判断中的临床意义。方法选择80例因ACI入我院住院治疗的患者为观察组，于治疗前和治疗第3、7、14天取血检测纤维蛋白原与D-二聚体水平；以40名社区健康老年人为正常对照组。于治疗前和治疗第3、7、14天取血检测纤维蛋白原与D-二聚体水平。结果正常对照组纤维蛋白原水平为（3．5±1．0）g／L，D-二聚体（0．4±0．1）g/L，观察组治疗前，治疗第3、7、14天纤维蛋白原和D-二聚体分别为（12．7±3．2）g/L，（1．8±0．3）g／L；（9．6±5．0）g/L，（1．4±0．7）g/L；（6．6±3．4）g/L，（0．9±0．3）g/L；（3．7±1．0）g／L，（0．6±0，4）g／L。观察组治疗前与治疗第3、7天二指标水平均明显高于对照组（P〈0．05）；治疗第3、7、14天二指标水平均明显低于治疗前（均P〈0．05）。结论纤维蛋白原与D-二聚体水平检测对患者的病情评估具有一定的临床价值。

Objective To observe the changes of fibrinogen and D-dimer in acute cerebral infarction （ACI） patients before and after treatment, and to investigate the clinical significance. Metbods Eighty patients of ACI were chosen as the observation group; 40 patients of community healthy elderly were chosen as the control group. All patients had blood test of fibrinogen and D-dimer before treatment, 3, 7, 14 days after treatment. The results were eomparated and analyzed. Results The levels of fibfinogen and D- two dimer in normal control group were（3.5 ±1 ） g/L, （0.4 ± 0.1） g/L respectively; those in the observation group before treatment, 3,7, 14 days after treatment were （12.7 ±3.2）g/L, （1.8 ±0.3）g/L; （9.6±5）g/L, （1.4 ±0.7）g/L; （6.6 ±3.4）g/L, （0.9 ± 0.3） g/L; （3.7 ±1 ） g/L, （0.6 ± 0.4） g/L respectively. The index in the observation group before treatment and after treatment all increased compared with control group （ P 〈 0. 05 ） ; compared with before treatment, fibrinogen and D- dimer in the observation group 3, 7, 14 days after treatment decreased （all P 〈 0. 05 ）. Conclusion Fibrinogen and D-dimer have close ties with ACI.