尖瓣瑞香化学成分研究

Chemical constituents from Daphne acutiloba

目的:研究尖瓣瑞香Daphne acutiloba中的化学成分。方法:采用硅胶柱色谱与Sephadex LH-20凝胶柱色谱进行分离纯化,并运用波谱方法对所分离的化合物进行结构鉴定。结果:从尖瓣瑞香中分离鉴定了15个化合物,经波谱解析鉴定为wikstroelide M(1),vesiculosin(2),prostratin(3),7-hydroxy-coumarin(4),7,8-dihydroxy-coumarin(5),isodaphnoside(6),daph-norine(7),rutamontine(8),daphnolin(9),daphneticin(10),(+)-pinoresinol-β-D-glucoside(11),oleodapnone(12),oleodaphnal(13),ergosterol peroxide(14)和cholest-5-en-3β-ol(15)。结论:除化合物4,5和14外其他成分均为首次从尖瓣瑞香中分离得到。

Objective： To study the chemical constituents from Daphne acutiloba. Method： The constituents were separated by column chromatography, and their structures were elucidated by spectroscopic data analyses. Result： Fifteen compounds were isola- ted from the EtOAc extract and identified as wikstroelide M （1）, vesieulosin （2）, prostratin （3）, 7-hydroxy-coumarin （4）, 7,8-di- hydroxy-eoumarin （ 5）, isodaphnoside （6）, daphnorine （7）, rutamontine （ 8 ）, daphnolin （9）, daphnetiein （10）, （ ＋ ） -pinores- inol-β-D-glueoside （ 11 ）, oleodapnone （ 12 ）, oleodaphnal （ 13 ）, ergosterol peroxide （ 14 ） and cholest-5-en-3β-ol （ 15 ）. Conclu- sion ： All the compounds except for 4, 5 and 14 were obtained from the stems of this plant for the first time.