药材道地性的物质基础本质:组分结构的独特性

Essence of material base in geoherbs:specificality of constituent structure

道地药材是久经中医临床验证的中华民族的瑰宝,在中医药临床的防病治病中扮演着不可或缺的角色。道地药材具有质量佳、疗效好等优点,其根本原因是内在化学成分/组分的外在表现。经过近些年的研究,道地药材化学特征的研究与创新取得了一些可喜的成果,但依然有许多问题困惑着研究者。越来越多的研究显示,道地药材发挥上佳药效的物质基础不是其含有独特的某一化学成分,而是含有独特的化学成分/组分构成的稳定有序的结构特征。"组分结构理论"认为道地药材的物质基础是由各组分构成,各组分之间具有稳定的配伍配比关系;组分内由各活性成分之间也具有稳定的配伍配比;而单独的活性成分,本身也具有独特的三维结构。该文基于"组分结构理论",从"三个层次多维结构"深入的阐述道地药材化学组成的独特性,为道地药材物质基础本质的研究提供新的新思路和方法。

Geoherbs, playing an indispensable role in the protection and the treatment of disease, has been demonstrated to be the treasure in Chinese medicine clinical. Geoherbs possessed the best quality and curative effect due to their distinctive inside chemi- cal ingredients/components. In recent years, a lot of achievements were obtained in geoherbs research on chemistry; however, there was also much confusion in existence. More and more studies revealed that the better curative effect on geoherbs was attributed to its ar- chitectural feature with steady and well-organized in unique ingredients/components constituent, but not for the characteristic single chemical ingredient. The ＂constituent structure theory＂ suggested that the material base of geoherbs consist of different components of which compatibility proportion relationship was optimal. In addition, the single active ingredients had their unique three-dimensional structure. This paper explained the peculiarity of geoherbs material base based on constituent structure theory from there layers and multi-dimensional structure to geoherbs material base research in a new way.