新生儿缺氧缺血性脑病发病和预后影响因素的调查分析

Investigation of pathogenic and prognostic influencing factors of HIE

目的调查新生儿缺氧缺血性脑病(HIE)发病和预后的相关因素,为临床治疗提供依据。方法选择住院治疗HIE患儿200例及正常新生儿200例为调查对象,对可能与HIE发病的相关因素进行调查和统计分析,并对有统计学意义的因素进行相关性分析。结果 66%的患儿出生后1 min Apgar评分<7分,60%的患儿出生后5 min Apgar评分<7分。87%的患儿治疗后情况好转或治愈。妊高征、妊娠期贫血、产程异常、胎盘异常、脐带异常、羊水污染是HIE发病的危险因素,而母亲文化程度与HIE发病负相关。胎盘因素、脐带因素、5 min Apgar评分、住院时间是影响预后的相关因素。结论影响HIE发病和预后的因素很多,了解掌握这些因素,做好孕期保健,及时发现及治疗可以达到预防和改善预后的目的。

Objective To investigate pathogenic and prognostic influencing factors of HIE. Methods Selected 200 cases with HIE and health newborn 200 cases as respondent. The reletant factors were invested and analyzed, and the correlation with the factors and HIE were analyzed. Results The ratio of Apgar score at 1 min after born less than 7 was 66%; 5 min was 60%. Improved and cure cases accounted for 87%. Pregnancy induced hypertension, pregnancy associated pregnancy associated, abnormal process, placenta anomaly, abnormality of umbilical cord and meconiumstained amniotic fluid were hazards of HIE. Degree of education of mother was negative correlation with HIE. Placenta anomaly, abnormality of umbilical cord, Apgar score at 5 min after born and hospital stays were influencing factors of prognosis. Conclusion There are a lot of pathogenic and prognostic influencing factors of HIE. To know these factors, and to do pregnancy care, and treated in time, can prevent HIE and improve prognosis.