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S100A13和FGF-1的分子生物学研究进展

The molecular biological progress of S100A13 and FGF-1
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摘要 S100A13属于钙结合蛋白家族的成员。成纤维细胞生长因子1(FGF-1)不能通过经典的内质网-高尔基体途径释放。但FGF-1与S100A13可结合成多蛋白释放复合体,实现跨磷脂膜的出胞转运,而发挥其生物学作用。S100A13与FGF-1在肿瘤及心血管疾病中均有表达,在疾病的病理过程中有重要作用。 S100A13 is a member of calcium - binding protein family. FGF-1 cannot be released through the classi- cal endoplasmic reticulum and Golgi pathway. By combination of multiple protein release complex and realization of exocytosis transport transmembrane phospholipid membrane, FGF-1 and SIOOA13 play an important biological role. SIOOA13 and FGF-1 are expressed in tumor and cardiovascular diseases. It is important to study pathology of disease processes
作者 贺雄辉 李灼日
机构地区 南华大学研究生学院临床医学系 海南省人民医院肝胆外科
出处 《中国现代医生》 2013年第3期38-39,共2页 China Modern Doctor
关键词 钙结合蛋白S100A13 成纤维细胞生长因子1 多蛋白释放复合体 S100A13 FGF-1 Multipleprotein release complex
分类号 R329.25 [医药卫生—人体解剖和组织胚胎学]
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参考文献18

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中国现代医生
2013年 第3期

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