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丙种球蛋白无反应型川崎病小儿临床特征分析 被引量：7

Clinical features of intravenous immunoglobulin-resistant Kawasaki disease in children
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摘要 目的分析静脉注射丙种球蛋白(IVIG)无反应型川崎病患儿的临床特点及危险因素,并探讨其治疗及预后。方法对住院治疗的102例川崎病患儿病例进行回顾性分析。结果与反应组相比,无反应组患儿总发热天数明显延长,冠状动脉病变、心电图ST-T段改变的发生率明显升高。治疗前ST-T段改变和发热天数较长是发生IVIG无反应的危险因素。结论 IVIG无反应型川崎病较IVIG反应型川崎病发热时间延长,更易发生冠状动脉病变及心电图ST-T段改变。治疗前ST-T段改变和发热天数较长的患儿发生IVIG无反应的可能性更高。 Objective The present study was designed to analyse the clinical features of intravenous immunoglobulin- resistant Kawasaki disease in children. Method A retrospective analysis of 102 hospitalized children with Kawasaki disease was conducted. Result Compared with those of intravenous immunoglobulin responders of Kawasaki disease cases, children with intravenous immunoglobulin-resistant Kawasaki disease had a prolonged duration of fever, and increased morbidity of coronary artery lesions and ST-T abnormalities in ECG. ST-T abnormalities in ECG before treatment and prolonged duration of fever are risks for intravenous immunoglobulin-resistant Kawasaki disease. Con- clusions Children with intravenous immunoglobulin-resistant Kawasaki disease had a longer duration of fever and an increased rate of abnormal ST-T changes in ECG. Children having a longer duration of fever and abnormal ST-T have an increased possibility to have intravenous immunoglobulin-resistant Kawasaki disease.
作者 何兵 杨锦艳 李小欧 金红芳
机构地区 武汉大学人民医院儿科 北京大学第一医院儿科
出处 《中国医刊》 CAS 2013年第1期33-36,共4页 Chinese Journal of Medicine
关键词 川崎病 丙种球蛋白 临床特征 Intravenous immunoglobulin-resistant Kawasaki disease Clinical feature
分类号 R725.4 [医药卫生—儿科]
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参考文献11

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共引文献620

同被引文献109

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引证文献7

二级引证文献62

中国医刊
2013年 第1期

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