PICC和CVC在肿瘤化疗中应用的效果评价

A comparative research of peripherally inserted central catheter and central venom catheter in cancer chemotherapy

目的分析经外周中心静脉置管（PICC）与中心静脉置管（CVC）2种置管方式在肿瘤化疗中应用的差别。方法全面检索中国期刊全文数据库、万方期刊数据库、维普期刊全文数据库，收集关于PICC与CVC在肿瘤化疗中应用的相关研究，采用Jadad量表对所有纳入的文献进行证据质量评价，运用统计学软件Stata对13项观察指标进行Meta分析。结果纳入36项研究，共4920例患者，其中PICC组2349例，CVC组2571例。PICC组的首次穿刺成功率、平均穿刺时间、平均导管留置时间均明显优于CVC组。PICC组的血气胸发生率、误入动脉发生率、导管感染发生率均低于CVC组，但静脉炎发生率高于CVC组。结论PICC具有操作简便，留置管时间长，并发症少，安全性高等优点，可广泛应用于肿瘤化疗。

Objective To analyze the difference of the peripherally inserted central venous catheter （PICC） and central venous catheter （CVC） in cancer chemotherapy. Methods All eligible studies on PICC and CVC were searched in China National Knowledge Infrastructure,Wanfang database and VIP database. The Jadad scale was used for quality assessment of all the included studies. All analysis were con- ducted in Stata 12.0. Results Thirty-six studies with a total of 4920 cases of patients were included in this meta-analysis,with 2349 cases in PICC group and 2571 cases in CVC group. PICC group had advan- tages in puncture success rate for the first time,the average puncture time, the average catheter time than the CVC group. PICC group had fewer complication,such as the hemopneumothorax incidence, the strayed artery incidence and catheter infection incidence; however, the phlebitis incidence was higher than the CVC group. Conclusions PICC has some advantages specific in simple operation, a long retention time, fewer complications and safety. Therefore, PICC can be widely used in cancer chemotherapy.