双径路化疗联合放疗治疗非小细胞肺癌MPE的疗效

Comparison of the therapeutic effect of double-way chemotherapy combined with radiotherapy in the treatment of NSCLC Patients with malignant pleural effusion

目的观察双径路化疗联合三维适形放疗治疗NSCLC恶性胸腔积液的疗效、患者的生活质量及毒副作用。方法36例确诊为NSCLC恶性胸腔积液的患者,按治疗方法随机分为A、B组,每组18例,A组:双径路化疗联合三维适形放疗;B组:单纯双径路化疗,两组患者均给予相同常规支持对症治疗,观察并比较两组的疗效、毒副作用及患者的生活质量。结果 A组有效率为94.4%,B组有效率61.1%(P<0.01);两组不良反应发生率差异无统计学意义(P>0.05);A组Karnofsky评分较B组有显著提高(P<0.05);A组总生存期较B组有显著延长(P<0.05)。结论双径路化疗联合三维适形放疗治疗NSCLC恶性胸腔积液的短期疗效优于单纯双径路化疗。

Objective To observe the therapeutic effects, improvement of life quality, and toxic side effects of double-way chem- otherapy combined with radiotherapy in the treatment of NSCLC patients with malignant pleural effusion. Methods 36 NSCLC patients with malignant pleural effusion were randomly and evenly divided into two groups according to the therapeutic method. The group A was treated with double-way chemotherapy combined with three-dimensional conformal radiotherapy, and the group B was treated with double road chemotherapy only. Besides, all of the patients were given routine and symptomatic treatment. The therapeutic effects, life quality and toxic side effects were evaluated and compared between the two groups. Results The effective rates were 94.4% and 61.1% respec- tively in the group A and the group B （P 〈0. 01 ）. There was no significant difference of toxic side effects between the group A and the group B （ P 〉 0. 05 ）. The Karnofsky score of the group A was higher than that of group B （ P 〈 0. 05 ）. The overall survival of the group A was significantly longer than that of the group B （ P 〈 0. 05 ）. Conclusion It is more effective for patients with malignant pleural effu- sion caused by NSCLC treated with double-way chemotherapy combined with three-dimensional conformal radiotherapy than double-way chemotherapy only.