COPD患者急性加重期的细菌学分析

Bacteriologic analysis on chronic obstructive pulmonary disease patients during acute exacerbation period

目的观察AECOPD患者的病原菌种类及耐药情况。方法收集258例AECOPD患者的痰培养及药敏结果进行分析。结果痰标本中分离出142株致病菌,其中革兰氏阴性菌(G-)(76.1%),革兰氏阳性菌(G+)(19.7%),白色念珠菌占4.2%。对革兰氏阴性杆菌有效的抗生素为碳青酶烯类、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦、头孢吡肟和阿米卡星等。革兰氏阳性球菌对万古霉素、替考拉宁、利奈唑胺耐药率低。结论 AECOPD患者呼吸道感染的病原菌以革兰氏阴性菌为主,应根据药敏结果合理地选用抗生素。

Objective To observe the pathogenic bacteria species and drug resistance of AECOPD patients. Methods Collected the sputum cultures and antimicrobial susceptibility test results of 258 AECOPD inpatients. Results Isolated 142 strains of pathogenic bacteria from sputum samples, among which, major are gram-negative bacteria （ G- ） （76. 1% ）, gram positive bacteria （ G＋ ） （19. 7% ）, candlda albicans accounts for4. 2%. Effective antibiotics for gram-negative bacteria include carbon green enzyme of alkenes, piperacillin/sulbactam, cefoperazone/sulbactam, Cefepime and amy card star, etc. Gram-positive bacteria showed a low resistance to van- comycin, teicoplanin, linezolid. Conc｜usion The main pathogenic bacteria for respiratory infection of AECOPD is gram negative bacteria, it is necessary to reasonably choose antibiotics according to antimicrobial susceptibility test results.