支气管哮喘患者血浆TNF-α、IL-6和NT-proBNP的临床意义

Clinical significance of detection of TNF-α,IL-6,and NT-proBNP levels in patients with acute bronchial asthma

目的探讨支气管哮喘急性发作患者血浆TNF-α、IL-6和NT-proBNP的临床意义。方法采用RIA、荧光免疫分析和超敏免疫分析分别检测63例支气管哮喘急性发作患者的TNF-α、IL-6和NT-proBNP,并与42例对照组进行比较。结果63例支气管哮喘急性发作患者血浆TNF-α和IL-6、NT-proBNP水平较42例对照组明显增高(P均<0.01),治疗后症状缓解期,TNF-α和IL-6、NT-proBNP水平呈逐步下降,其中TNF-α和IL-6水平在症状缓解半月后与对照组比较无显著差异(P均>0.05)。结论血浆TNF-α、IL-6和NT-proBNP是支气管哮喘患者急性发作及治疗后缓解的有价值的指标。

Objective To explore the clinical significance of detection of TNF-a, IL-6, and NT-pmBNP levels in patients with acute bronchial asthma. Methods 63 patients with acute bronchial asthma were selected as the experiment group and 42 healthy people were taken as the control group. The levels of TNF-a, IL-6, and NT-proBNP were detected by radioimmunoassay （RIA）, fluorescence immunoassay and super-sensitivity immunoassay respectively. Then the results were compared. Results The levels of TNF-a and IL-6 were significantly higher in the experiment group than in the controls （ P 〈0. 01 ）. After the inhalation of glucocorticoid, the levels of TNF-a and IL-6 still increased significantly （ P 〈 0.05 ）, and half month after, the levels were back to normal value. Conclusion The levels of TNF-a, IL-6, and NT-proBNP can be used as a valuable index to evaluate the curative effect of glucocorticoid inhalation in the treatment of patients with acute bronchial asthma.