58例非结核分枝杆菌肺病住院患者的临床分析

Clinical analysis of 58 inpatients with non-tuberculous mycobacterial pulmonary disease

目的了解非结核分支杆菌(NTM)肺病患者临床及耐药特点。方法分析上海市肺科医院确诊为NTM肺病的58例患者的临床资料。结果男女之比1.32∶1,平均年龄(60.5±12.8)岁。患者肺部均有斑片影,伴索条或结节。耐药率:异烟肼91.4%;利福平81.1%;乙胺丁醇75.5%;链霉素98.1%。氧氟沙星83.3%。阿米卡星91.9%。卷曲霉素94.6%。同时耐HR77.4%;SHREACpO全耐43.4%。结论 NTM肺病好发于中老年男性,肺部影像类似肺结核。NTM耐药率仍在增高,近半数SHREACpO全耐。

Objective To understand the clinical features and drug resistance of patients with non-tuberculous mycobacterial （NTM） lung disease. Methods The clinical data of 58 patients with NTM lung diseases were retrospectively analyzed. Results The ra- tio of male to female was 1.32 ： 1, and the average age was 60. 47 ＋ 12.75 years old. All of the patients had patchy shadows in their lungs, accompanied by streaks or nodules. The rate of drug resistance was as follows： 91.4% to retozide, 81.8% to RFP, 75.5% to ethambuto｜, 98.1% to streptomycin, 83.3% to ofloxacin, 91.9% to anfikacin, and 94. 6% to capreomycin. The rate of drug resistance to retozide and RFP at the same time was 77.4%, and the rate of drug resistance to all the above drugs was 43.4%. Conclusion NTM lung diseases occur mostly in middle-aged men, and its lung image is similar to tuberculosis. The drug resistance rate of NTM is still going high and nearly half of it shows resistance to all the above drugs. Therefore, it is important to develop individualized treatment programs based on the patients＇ condition.