Ki-67、PCNA和Survivin在胃肠道间质瘤组织中的表达

Expressions of Ki-67,PCNA and Survivin in gastrointestinal stromal tumor tissues

目的探讨Ki-67、PCNA和Survivin在胃肠道间质瘤(gastrointestinal stromal tumor,GIST)组织中的表达及其与GIST临床病理参数的关系。方法应用免疫组化SP法检测103例GIST组织中Ki-67、PCNA和Survivin的表达。结果 GIST组织中Ki-67、PCNA和Survivin阳性表达率分别为56.3%、68.0%、72.8%,Ki-67、PCNA和Sur-vivin表达与GIST的发生年龄、性别、部位、组织学类型无关,而与肿瘤的NIH分级有关,且Ki-67、PCNA与Survivin的表达呈显著性正相关。结论 Ki-67、PCNA和Survivin联合检测可作为判定GIST恶性程度及预后的重要指标。

Objective To investigate expressions of Ki-67, PCNA and Survivin in the gastrointestinal stromal tumor （GIST） tissues and the relationship with clinic pathological factors. Methods The SP immunohistochemical assay was used to detect the expressions of Ki-67, PCNA and Survivin in 103 cases with GIST. Results The Ki-67, PCNA and Survivin positive expression rates were 56.3%, 68.0% and 72.8%. There was no correlation between Ki-67, PCNA, Survivin expressions and the age, sex, location and histological type. The expressions of Ki-67, PCNA and Survivin were related to the NIH grade. There were significant positive correlations among Ki-67, PCNA and Survivin expressions. Conclusion Ki-67, PCNA and Survivin can be used as the predictor for the malignant degree and prognosis of GIST.